Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | RORA | P35398 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RORB | Q92753 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005436 | 0.80 | MAPT (0.38) | HTR7DAOCYP1A2CYP2A6MEN1 | |
| SCHEMBL7006296 | 0.78 | TP53 (0.38) | HTR7CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7006877 | 0.78 | HTR3E (0.37) | HTR7DAOCCNE2CDK4CCND1 | |
| SCHEMBL7006177 | 0.78 | DAO (0.36) | DAOCDK4CCND1SMN1; SMN2MEN1 | |
| SCHEMBL7005666 | 0.77 | DAO (0.41) | HTR7DAOPARP1CYP1A2CYP2A6 | |
| SCHEMBL7003133 | 0.76 | CA2 (0.44) | HTR7CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7004254 | 0.76 | DAO (0.46) | DAOPARP1TP53SMN1; SMN2MEN1 | |
| SCHEMBL7005787 | 0.75 | POLB (0.41) | SMN1; SMN2KDM4ETDP2L3MBTL1PLA2G10 | |
| SCHEMBL7007358 | 0.75 | CREBBP (0.39) | HPGDHSD17B10KDM4EMAPTALDH1A1 | |
| SCHEMBL7006729 | 0.73 | ALOX5 (0.48) | HTR7CCNE2CDK4CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |