Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735584 | 0.85 | ALOX5 (0.34) | IDO1SMN1; SMN2LMNA | |
| SCHEMBL9735568 | 0.85 | MAPT (0.35) | SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL9200740 | 0.85 | ABCC9 (0.41) | LMNA | |
| SCHEMBL9735552 | 0.80 | IDO1 (0.32) | IDO1 | |
| SCHEMBL9736485 | 0.79 | IDO1 (0.32) | IDO1SMN1; SMN2XIAPTP53 | |
| SCHEMBL9736148 | 0.78 | XIAP (0.32) | IDO1SMN1; SMN2XIAP | |
| SCHEMBL9735180 | 0.74 | HTR2B (0.33) | IDO1SMN1; SMN2XIAP | |
| SCHEMBL9736155 | 0.73 | XIAP (0.32) | IDO1SMN1; SMN2XIAPSIRT2 | |
| SCHEMBL26759016 | 0.70 | MEN1 (0.34) | IDO1SIRT2 | |
| SCHEMBL9845071 | 0.70 | XIAP (0.33) | IDO1SMN1; SMN2XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |