Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656458 | 0.90 | ALOX5 (0.40) | NOTUMALOX5 | |
| SCHEMBL9259627 | 0.75 | NOTUM (1.00) | NOTUMALDH1A1TSHR | |
| SCHEMBL30615209 | 0.75 | NOTUM (1.00) | NOTUMALDH1A1TSHR | |
| SCHEMBL7278393 | 0.67 | NOTUM (0.80) | NOTUMALDH1A1TSHR | |
| SCHEMBL12598325 | 0.65 | NOTUM (0.57) | NOTUMALDH1A1TSHR | |
| SCHEMBL18229909 | 0.63 | NOTUM (0.46) | NOTUMPLA2G10ALDH1A1TSHR | |
| SCHEMBL9736607 | 0.61 | NOTUM (0.39) | NOTUMALDH1A1TSHROPRM1OPRD1 | |
| SCHEMBL9656449 | 0.61 | ALOX5 (0.37) | ALOX5 | |
| SCHEMBL7379739 | 0.60 | NOTUM (0.62) | NOTUMALDH1A1TSHR | |
| SCHEMBL30684094 | 0.60 | CYP1A2 (0.40) | NOTUMALDH1A1TSHROPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |