Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR3 | O15455 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736155 | 0.86 | XIAP (0.32) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9737251 | 0.83 | HSD17B10 (0.34) | MAPTLMNASMN1; SMN2ALDH1A1ABCC9 | |
| SCHEMBL9737038 | 0.82 | AKR1B1 (0.33) | TLR3HTTMAPTLMNASMN1; SMN2 | |
| SCHEMBL9737706 | 0.78 | TLR3 (0.35) | TLR3HTTMAPTLMNASMN1; SMN2 | |
| SCHEMBL7965091 | 0.76 | TLR3 (0.40) | TLR3HTTMAPTLMNASMN1; SMN2 | |
| SCHEMBL9736573 | 0.75 | MAPT (0.36) | TLR3HTTMAPTLMNASMN1; SMN2 | |
| SCHEMBL9737011 | 0.74 | PNMT (0.34) | MAPTSMN1; SMN2DRD2HTR2AALDH1A1 | |
| SCHEMBL9735568 | 0.74 | MAPT (0.35) | TLR3HTTMAPTLMNASMN1; SMN2 | |
| SCHEMBL9735535 | 0.74 | KMT2A (0.36) | TLR3HTTMAPTLMNASMN1; SMN2 | |
| SCHEMBL9734741 | 0.72 | ABCC9 (0.52) | TLR3HTTMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |