Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736655 | 0.80 | KDM4E (0.37) | KDM4ERECQLMAPTPTGES2AKR1B10 | |
| SCHEMBL10727157 | 0.72 | KDM4E (0.53) | KDM4ERECQLMAPTMAPK1KMT2A | |
| SCHEMBL9738190 | 0.65 | RAD52 (0.33) | KDM4EPTGES2MEN1KMT2ATRPA1 | |
| SCHEMBL10726787 | 0.64 | KDM4E (0.53) | KDM4ERECQLMAPTMAPK1KMT2A | |
| SCHEMBL14445624 | 0.60 | HTT (0.57) | MAPK1 | |
| SCHEMBL16017509 | 0.59 | MTNR1A (0.39) | KDM4EMAPTMEN1KMT2ATRPA1 | |
| SCHEMBL8687445 | 0.59 | PTGES2 (0.43) | KDM4EPTGES2MEN1KMT2ATRPA1 | |
| SCHEMBL12083594 | 0.59 | RORA (0.46) | KDM4EMAPTMEN1KMT2ATRPA1 | |
| SCHEMBL25765617 | 0.59 | MEN1 (0.45) | MEN1KMT2ATRPA1PTGS1CACNA1C | |
| SCHEMBL22178735 | 0.58 | PARP15 (0.38) | TRPA1PTGS1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |