Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RORA | P35398 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RORB | Q92753 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737883 | 0.80 | KDM4E (0.63) | KDM4ERECQLMEN1KMT2AATM | |
| SCHEMBL9844706 | 0.75 | KDM4E (0.60) | KDM4ERECQLMAPTPABPC1TP53 | |
| SCHEMBL10729878 | 0.71 | ALDH1A1 (0.41) | KDM4ERECQLMEN1KMT2AMAPT | |
| SCHEMBL10725922 | 0.67 | KDM4E (0.54) | KDM4ERECQLMAPTPABPC1TP53 | |
| SCHEMBL9738190 | 0.65 | RAD52 (0.33) | KDM4EMEN1KMT2APTGES2TP53 | |
| SCHEMBL15341928 | 0.62 | RORA (0.48) | KDM4EMEN1KMT2AATMMAPT | |
| SCHEMBL8687445 | 0.62 | PTGES2 (0.43) | KDM4EMEN1KMT2ARORARORC | |
| SCHEMBL12083594 | 0.61 | RORA (0.46) | KDM4EMEN1KMT2AMAPTRORA | |
| SCHEMBL25765617 | 0.61 | MEN1 (0.45) | MEN1KMT2ARORARORCRORB | |
| SCHEMBL26398797 | 0.60 | RORA (0.42) | RORARORCRORBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |