Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737169 | 0.74 | ALOX5 (0.34) | PTGES2MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL9736655 | 0.65 | KDM4E (0.37) | PTGES2MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL9737883 | 0.65 | KDM4E (0.63) | PTGES2MEN1KMT2AKDM4ETRPA1 | |
| SCHEMBL15341790 | 0.58 | CNR1 (0.44) | CYP1A2 | |
| SCHEMBL8687445 | 0.58 | PTGES2 (0.43) | PTGES2MEN1KMT2AKDM4ETRPA1 | |
| SCHEMBL25765617 | 0.58 | MEN1 (0.45) | MEN1KMT2ATRPA1PTGS1CACNA1C | |
| SCHEMBL12083594 | 0.58 | RORA (0.46) | MEN1KMT2AHSD17B10KDM4EHTR1D | |
| SCHEMBL15341787 | 0.58 | CNR1 (0.46) | — | |
| SCHEMBL26398797 | 0.57 | RORA (0.42) | HTR1DHTR1BTRPA1PTGS1CACNA1C | |
| SCHEMBL24667912 | 0.56 | BCHE (0.45) | MEN1KMT2AHSD17B10KDM4ETRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |