Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740480 | 0.76 | CASP1 (0.31) | CASP1 | |
| SCHEMBL9736281 | 0.69 | PIK3CD (0.34) | ALDH1A1NPSR1 | |
| SCHEMBL9735772 | 0.67 | MAPT (0.40) | MAPTPOLBSMN1; SMN2TP53 | |
| SCHEMBL29573275 | 0.65 | ATM (0.42) | ALDH1A1CTSLPOLBCASP1SMN1; SMN2 | |
| SCHEMBL9736737 | 0.65 | PIK3CD (0.34) | — | |
| SCHEMBL8991280 | 0.64 | ALDH1A1 (0.48) | ALDH1A1MAPTPOLBSMN1; SMN2NPSR1 | |
| SCHEMBL13691987 | 0.64 | CYP3A4 (0.46) | ALDH1A1POLBCASP1SMN1; SMN2 | |
| SCHEMBL28580670 | 0.64 | CYP3A4 (0.46) | ALDH1A1POLBCASP1SMN1; SMN2 | |
| SCHEMBL13534716 | 0.64 | CYP3A4 (0.46) | ALDH1A1POLBCASP1SMN1; SMN2 | |
| SCHEMBL12540247 | 0.64 | CYP3A4 (0.46) | ALDH1A1POLBCASP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5138050-A | 6-amido-1-methyl carbapenems | MERCK & CO., INC. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0350211-A2 | Novel 6-amido-1-methyl carbapenems | MERCK & CO. INC. (US) | 1990-01-10 | — | — | EP | disclosed |