Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740476 | 0.73 | ALDH1A1 (0.32) | TMEM97SIGMAR1 | |
| SCHEMBL8991213 | 0.73 | GAA (0.52) | MAPTGAATP53LMNAPOLB | |
| SCHEMBL7964858 | 0.70 | ADRA1B (0.49) | TMEM97SIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL9738423 | 0.67 | ALDH1A1 (0.40) | MAPTTP53POLBSMN1; SMN2 | |
| SCHEMBL8472442 | 0.67 | SMN1; SMN2 (0.55) | MAPTGAALMNASMN1; SMN2HTT | |
| SCHEMBL22710272 | 0.67 | TDP1 (0.59) | MAPTTMEM97SIGMAR1HTR1AADRA1D | |
| SCHEMBL10886269 | 0.67 | MAPT (0.48) | MAPTGAATP53LMNAPOLB | |
| SCHEMBL10367463 | 0.64 | TMEM97 (0.47) | TMEM97SIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL25417926 | 0.63 | TMEM97 (0.49) | MAPTTMEM97SIGMAR1LMNANAMPT | |
| SCHEMBL8994562 | 0.63 | TDP1 (0.53) | MAPTHTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5138050-A | 6-amido-1-methyl carbapenems | MERCK & CO., INC. (US) | 1992-08-11 | — | — | US | disclosed |
| WO-1990000170-A1 | NOVEL 6-AMIDO-1-METHYLCARBAPENEMS | MERCK & CO., INC. (US) | 1990-01-11 | — | — | WO | disclosed |
| EP-0350211-A2 | Novel 6-amido-1-methyl carbapenems | MERCK & CO. INC. (US) | 1990-01-10 | — | — | EP | disclosed |