Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | RGS12 | O14924 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.55 |
| ▸ | THRA | P10827 | 7/20 | 0.55 |
| ▸ | THRB | P10828 | 7/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696757 | 0.81 | PLA2G2A (0.69) | LMNAALDH1A1HIF1APKMMEN1 | |
| SCHEMBL16494825 | 0.80 | HTR6 (0.64) | LMNAALDH1A1KMT2ATSHRMAPK1 | |
| SCHEMBL3030239 | 0.79 | MTNR1A (0.61) | LMNAALDH1A1HIF1APKMMEN1 | |
| SCHEMBL11332785 | 0.77 | MTNR1A (0.59) | LMNAALDH1A1HIF1APKMMEN1 | |
| SCHEMBL12628559 | 0.76 | LMNA (0.57) | LMNAALDH1A1HIF1APKMMEN1 | |
| SCHEMBL13228557 | 0.76 | LMNA (0.59) | LMNAALDH1A1HIF1APKMMEN1 | |
| SCHEMBL20787916 | 0.75 | CACNB4 (0.51) | ALDH1A1MAPTTHRATHRBNPSR1 | |
| SCHEMBL12628346 | 0.75 | BCHE (0.56) | LMNAALDH1A1PLA2G2A | |
| SCHEMBL13849520 | 0.74 | LMNA (0.54) | LMNAALDH1A1HIF1APKMMEN1 | |
| SCHEMBL8600343 | 0.74 | SLC22A12 (0.67) | LMNAALDH1A1HIF1APKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166591-B1 | INDOLE-2-ALKANOIC ACIDS AND THEIR USE AS PROSTAGLANDIN ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1989-11-23 | — | — | EP | claimed |
| EP-0166591-A2 | Indole-2-alkanoic acids and their use as prostaglandin antagonists | MERCK FROSST CANADA INC. (CA) | 1986-01-02 | — | — | EP | claimed |
| US-5081145-A | Contractile prostaglandin antagonists | MERCK FROSST CANADA, INC. (CA) | 1992-01-14 | — | — | US | disclosed |
| EP-0166591-B1 | INDOLE-2-ALKANOIC ACIDS AND THEIR USE AS PROSTAGLANDIN ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1989-11-23 | — | — | EP | disclosed |
| EP-0166591-A2 | Indole-2-alkanoic acids and their use as prostaglandin antagonists | MERCK FROSST CANADA INC. (CA) | 1986-01-02 | — | — | EP | disclosed |