Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738560 | 0.74 | ALDH1A1 (0.38) | KMT2APTGS2MEN1RECQLALDH1A1 | |
| SCHEMBL13802689 | 0.72 | TP53 (0.36) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL10703931 | 0.72 | MAPT (0.42) | KMT2APTGS2MEN1ALDH1A1MAPT | |
| SCHEMBL17684053 | 0.68 | OPRL1 (0.40) | PTGS2HTR2AHTR2CHTR2BTP53 | |
| SCHEMBL11201145 | 0.65 | TSHR (0.47) | KMT2APTGS2MEN1HTR2AHTR2C | |
| SCHEMBL9059555 | 0.65 | CHRNB2 (0.36) | KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL17684321 | 0.65 | PTGS2 (0.36) | KMT2APTGS2HTR2AHTR2CHTR2B | |
| SCHEMBL17683936 | 0.63 | OPRL1 (0.39) | PTGS2HTR2AHTR2CHTR2BTP53 | |
| SCHEMBL17683935 | 0.63 | OPRL1 (0.39) | PTGS2HTR2AHTR2CHTR2BTP53 | |
| SCHEMBL9667454 | 0.63 | PTGS2 (0.35) | PTGS2HTR2AHTR2CHTR2BTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082842-A | Sedatives | HOFFMANN-LA ROCHE INC. (US) | 1992-01-21 | — | — | US | disclosed |
| US-4889854-A | MUSCLE RELAXANT, SEDATIVE-HYPNOTIC, ANXIOLYTIC AND-OR ANTICONVULSANT ACTIVITY | HOFFMAN-LA ROCHE INC. (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0294599-A2 | Tricyclic pyridone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-12-14 | — | — | EP | disclosed |