Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207074 | 0.95 | GRM5 (0.42) | GRM5SIGMAR1HRH3 | |
| SCHEMBL9214818 | 0.95 | SLC6A4 (0.42) | GRM5SIGMAR1ACHEHDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL9213427 | 0.94 | GRM5 (0.42) | GRM5SIGMAR1HRH3 | |
| SCHEMBL9215558 | 0.93 | GRM5 (0.41) | GRM5SIGMAR1HDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL9213668 | 0.88 | ABCB1 (0.46) | GRM5ACHESLC6A4HTR1ADRD4 | |
| SCHEMBL9213420 | 0.88 | HRH3 (0.46) | GRM5SIGMAR1SLC6A4HTR1AHRH3 | |
| SCHEMBL9213007 | 0.84 | GRM5 (0.38) | GRM5SIGMAR1ACHEHTR1ADRD4 | |
| SCHEMBL9215099 | 0.83 | ADRA1B (0.46) | SIGMAR1ACHESLC6A4HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL9208899 | 0.83 | CHRNB2 (0.46) | GRM5HTR1ADRD4ABCB1 | |
| Hydrochloric Acid SCHEMBL9216230 | 0.83 | GRM5 (0.37) | GRM5SIGMAR1ACHEHTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |