Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207074 | 0.97 | GRM5 (0.42) | GRM5HRH3SIGMAR1CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL9213427 | 0.96 | GRM5 (0.42) | GRM5HRH3SIGMAR1CHRNB2CHRNB4 | |
| SCHEMBL9213420 | 0.95 | HRH3 (0.46) | GRM5HRH3SIGMAR1BCHEPRMT5 | |
| SCHEMBL9739700 | 0.93 | GRM5 (0.41) | GRM5HRH3SIGMAR1HDAC3HDAC4 | |
| SCHEMBL9213761 | 0.90 | CHRNB2 (0.43) | GRM5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9214818 | 0.88 | SLC6A4 (0.42) | GRM5HRH3SIGMAR1HDAC3HDAC4 | |
| SCHEMBL9740802 | 0.86 | SIGMAR1 (0.45) | GRM5SIGMAR1BCHECHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL9208899 | 0.85 | CHRNB2 (0.46) | GRM5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9215804 | 0.83 | GRM5 (0.39) | GRM5HRH3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9208130 | 0.82 | HRH3 (0.44) | GRM5HRH3SIGMAR1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |