Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739935 | 0.83 | ATM (0.46) | AKR1B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9711252 | 0.78 | TSHR (0.36) | ALDH1A1SMN1; SMN2L3MBTL1KMT2AVCAM1 | |
| SCHEMBL3331992 | 0.78 | AKR1B1 (0.45) | AKR1B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9740686 | 0.76 | HSD11B1 (0.41) | ALDH1A1L3MBTL1KMT2AMAPTHSD11B1 | |
| SCHEMBL68990 | 0.75 | TRPV4 (0.58) | AKR1B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29651884 | 0.75 | TRPV4 (0.58) | AKR1B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28077457 | 0.73 | MMP2 (0.41) | AKR1B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9711269 | 0.72 | SOS1 (0.42) | AKR1B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27619523 | 0.71 | AKR1B1 (0.49) | AKR1B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9711152 | 0.71 | HSD11B1 (0.41) | ALDH1A1L3MBTL1TDP1KMT2AVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |