Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740376 | 0.83 | TSHR (0.42) | HSP90AA1SLC40A1KMT2AL3MBTL1TDP1 | |
| SCHEMBL9740686 | 0.83 | HSD11B1 (0.41) | HSD11B1HSP90AA1KMT2AL3MBTL1GAA | |
| SCHEMBL9711155 | 0.81 | ALDH1A1 (0.39) | KMT2AL3MBTL1GAATDP1ALDH1A1 | |
| SCHEMBL9739733 | 0.78 | HSP90AA1 (0.43) | HSD11B1HSP90AA1KMT2AL3MBTL1VCAM1 | |
| SCHEMBL9652718 | 0.76 | ALDH1A1 (0.43) | HSD11B1KMT2AGAATDP1ALDH1A1 | |
| SCHEMBL9711168 | 0.75 | SOD1 (0.49) | KMT2AVCAM1 | |
| SCHEMBL350041 | 0.75 | HSD11B1 (0.50) | HSD11B1EDNRBEDNRASLC40A1KMT2A | |
| SCHEMBL9711252 | 0.74 | TSHR (0.36) | KMT2AL3MBTL1VCAM1ALDH1A1 | |
| SCHEMBL9711256 | 0.73 | KIF18A (0.37) | HSD11B1TDP1ALDH1A1 | |
| SCHEMBL7106883 | 0.73 | HSD11B1 (0.51) | HSD11B1EDNRBEDNRASLC40A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | claimed |
| EP-0304190-B1 | (ARYLSULPHONYL)NITROMETHANES, PROCESS FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-08 | — | — | EP | claimed |
| EP-0304190-A1 | (Arylsulphonyl)nitromethanes, process for their preparation and use in pharmaceutical compositions | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-02-22 | — | — | EP | claimed |
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0304190-B1 | (ARYLSULPHONYL)NITROMETHANES, PROCESS FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-08 | — | — | EP | disclosed |
| EP-0304190-A1 | (Arylsulphonyl)nitromethanes, process for their preparation and use in pharmaceutical compositions | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-02-22 | — | — | EP | disclosed |