Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 4/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.35 |
| ▸ | GPX4 | P36969 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL977229 | 0.93 | OPRD1 (0.35) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL978279 | 0.91 | OPRD1 (0.34) | SLC6A9CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL975245 | 0.91 | SLC6A9 (0.39) | SLC6A9CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL977213 | 0.90 | OPRD1 (0.33) | SLC6A9TBXA2ROPRD1CCR5PTGDR | |
| Drinabant SCHEMBL684143 | 0.90 | CYP3A4 (0.36) | SLC6A9CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL977021 | 0.89 | SLC6A9 (0.36) | SLC6A9CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL975366 | 0.89 | KCNH2 (0.36) | SLC6A9CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL977115 | 0.89 | F2 (0.42) | SLC6A9CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL977372 | 0.88 | OPRD1 (0.36) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL977822 | 0.88 | MEN1 (0.37) | SLC6A9CACNA2D1CACNA1BCACNB1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130237513-A1 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI (FR) | 2013-09-12 | — | — | US | disclosed |
| US-8445478-B2 | Azetidine derivatives, their preparation and their application in therapy | SANOFI (FR) | 2013-05-21 | — | — | US | disclosed |
| US-20110183961-A1 | AZETIDINE POLYSUBSTITUTED COMPOUNDS, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2011-07-28 | — | — | US | disclosed |
| US-20110152236-A1 | AZETIDINE POLYSUBSTITUTED COMPOUNDS, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2011-06-23 | — | — | US | disclosed |
| US-20110053908-A1 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2011-03-03 | — | — | US | disclosed |
| US-20110009377-A1 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI-AVENTIS (FR) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053908-A1 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | QDPR, NHERF1, GABRR1 | SLC6A9 379/4885CACNA2D1 1878/4885CACNA1B 753/4885 |
| US-20130237513-A1 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | QDPR, AZI2, ADRA1B | SLC6A9 2158/4885CACNA2D1 2643/4885CACNA1B 1231/4885 |
| US-20110009377-A1 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | QDPR, AZI2, ADRA1B | SLC6A9 2158/4885CACNA2D1 2643/4885CACNA1B 1231/4885 |
| US-20110152236-A1 | AZETIDINE POLYSUBSTITUTED COMPOUNDS, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | C1R, TACR1, C1S | SLC6A9 100/4885CACNA2D1 3134/4885CACNA1B 760/4885 |
| US-20110183961-A1 | AZETIDINE POLYSUBSTITUTED COMPOUNDS, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | C1R, C1S, TACR1 | SLC6A9 334/4885CACNA2D1 3388/4885CACNA1B 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.