Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 8/20 | 0.40 |
| ▸ | RARB | P10826 | 8/20 | 0.40 |
| ▸ | RARG | P13631 | 8/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.37 |
| ▸ | RXRA | P19793 | 5/20 | 0.36 |
| ▸ | RXRB | P28702 | 2/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | HNF4A | P41235 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9746659 | 0.87 | RARA (0.59) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL9746771 | 0.79 | RARA (0.51) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL9746456 | 0.78 | RARA (0.63) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL6147281 | 0.74 | RXRA (0.44) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL10834477 | 0.72 | RARB (0.59) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL2095481 | 0.71 | RXRA (0.57) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL6147303 | 0.70 | RXRA (0.47) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL6147305 | 0.70 | RXRA (0.47) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL9747138 | 0.70 | TDP1 (0.41) | RARARARBRARGCYP26A1CYP26B1 | |
| SCHEMBL9507898 | 0.69 | PPARG (0.50) | RARARARBRARGCYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220118-B1 | BICYCLIC NAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINE AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1992-01-02 | — | — | EP | claimed |