Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10553104 | 0.78 | PRKCI (0.35) | PRKCIALOX5ALDH1A1KDM4EHPGD | |
| SCHEMBL9747175 | 0.69 | PRKCI (0.42) | PRKCIALOX5ALDH1A1KDM4EHPGD | |
| SCHEMBL9027495 | 0.68 | PTPN1 (0.50) | PRKCIALOX5KDM4EHSD17B10PPARG | |
| SCHEMBL9029445 | 0.66 | ALOX5 (0.60) | PRKCIALOX5ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13116411 | 0.65 | ALDH1A1 (0.38) | ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9739521 | 0.65 | PRKCI (0.56) | PRKCIALOX5ALDH1A1KDM4EHPGD | |
| SCHEMBL17804010 | 0.63 | ALDH1A1 (0.36) | ALDH1A1KDM4EHPGD | |
| SCHEMBL13116342 | 0.63 | CA2 (0.35) | ALDH1A1KDM4EHPGD | |
| SCHEMBL9740854 | 0.62 | PRKCI (0.51) | PRKCIALOX5KDM4EHPGD | |
| SCHEMBL2924582 | 0.62 | THRB (0.39) | ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |