SCHEMBL9747729

SCHEMBL9747729

Nc1ccc(F)c(F)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
KIF11 P52732 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9747444 0.81 ALDH1A1 (0.36) ALDH1A1KIF11
SCHEMBL7871395 0.81 ALDH1A1 (0.36) ALDH1A1KIF11
SCHEMBL9629047 0.79 CES2 (0.39) CES2CES1
SCHEMBL6313808 0.79 KIF11 (0.36) ALDH1A1KIF11
SCHEMBL29620304 0.79 KIF11 (0.36) ALDH1A1KIF11
SCHEMBL24427744 0.77 CYP3A4 (0.33) ALDH1A1
SCHEMBL10215365 0.77 KDM1A (0.33)
SCHEMBL9748388 0.77 NOTUM (0.36) ALDH1A1
SCHEMBL112835 0.76 ALDH1A1 (0.43) ALDH1A1CES2CES1
SCHEMBL22507898 0.76 MEN1 (0.35) ALDH1A1CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5082971-A TRIFLUOROMETHYLAMINOBENZENES CONTAINING FLUORINE AND/OR CHLORINE AND THEIR PREPARATION BAYER AKTIENGESELLSCHAFT (DE) 1992-01-21 US claimed
EP-0315863-A2 Trifluoromethylamino benzenes containing fluorine, and their preparation BAYER AG (DE) 1989-05-17 EP claimed
WO-2022190859-A1 METAL NANOPARTICLE-CONTAINING DISPERSION COMPOSITION 株式会社ダイセル 2022-09-15 WO disclosed
US-5082971-A TRIFLUOROMETHYLAMINOBENZENES CONTAINING FLUORINE AND/OR CHLORINE AND THEIR PREPARATION BAYER AKTIENGESELLSCHAFT (DE) 1992-01-21 US disclosed
US-4963181-A Fungicidal 3-cyano-4-phenyl-pyrrole derivatives BAYER AKTIENGESELLSCHAFT (DE) 1990-10-16 US disclosed
US-4952601-A Fungicidal 3-cyano-4-phenyl-pyrrole derivatives BAYER AKTIENGESELLSCHAFT (DE) 1990-08-28 US disclosed
EP-0339422-A1 3-Cyano-4-phenyl-pyrrole derivatives BAYER AG (DE) 1989-11-02 EP disclosed
EP-0315869-A2 3-Cyano-4-(2,4-difluor-3-phenyl)-pyrrole BAYER AG (DE) 1989-05-17 EP disclosed
EP-0315863-A2 Trifluoromethylamino benzenes containing fluorine, and their preparation BAYER AG (DE) 1989-05-17 EP disclosed