Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.56 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.56 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.55 |
| ▸ | TYR | P14679 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 2/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748640 | 1.00 | ABCG2 (0.62) | ABCG2PTPN1PTGS1PTGS2GABRA3 | |
| SCHEMBL344390 | 0.88 | ALDH1A1 (0.63) | MAOBSLC5A1SLC5A2BACE1ALDH1A1 | |
| SCHEMBL344391 | 0.88 | ALDH1A1 (0.63) | MAOBSLC5A1SLC5A2BACE1ALDH1A1 | |
| SCHEMBL7196601 | 0.81 | GABRA3 (0.84) | ABCG2GABRA3GABRA2GABRB2MAOB | |
| SCHEMBL7196607 | 0.81 | GABRA3 (0.84) | ABCG2GABRA3GABRA2GABRB2MAOB | |
| SCHEMBL3046006 | 0.81 | ABCG2 (0.64) | ABCG2PTPN1PTGS1PTGS2MAOB | |
| SCHEMBL13029337 | 0.81 | ABCG2 (0.64) | ABCG2PTPN1PTGS1PTGS2MAOB | |
| SCHEMBL7046152 | 0.80 | MAOB (0.56) | PTGS1PTGS2MAOBLMNA | |
| SCHEMBL16242555 | 0.80 | ABCG2 (0.87) | ABCG2MAOBSLC5A1SLC5A2BACE1 | |
| SCHEMBL16242554 | 0.80 | ABCG2 (0.87) | ABCG2MAOBSLC5A1SLC5A2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120874-A | Process for the preparation of 5-hydroxydiprafenone and its acid addition salts | HELOPHARM W. PETRIK GMBH & CO. KG (DE) | 1992-06-09 | — | — | US | disclosed |
| EP-0283540-B1 | PROCESS FOR THE PREPARATION OF 5-HYDROXYDIPRAPHENONE AND ITS SALTS WITH ACIDS | Helopharm W. Petrik GmbH & Co.KG. (DE) | 1991-09-18 | — | — | EP | disclosed |