Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL502660 | 0.87 | — | — | |
| Water SCHEMBL28190481 | 0.87 | — | — | |
| Water SCHEMBL1305747 | 0.87 | — | — | |
| Water SCHEMBL2775514 | 0.87 | — | — | |
| Water SCHEMBL6858508 | 0.87 | — | — | |
| Water SCHEMBL20163220 | 0.75 | — | — | |
| Water SCHEMBL28294686 | 0.75 | — | — | |
| Water SCHEMBL7261161 | 0.75 | — | — | |
| Water SCHEMBL7724625 | 0.75 | — | — | |
| Water SCHEMBL23298299 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6330474-B1 | Annunciator for implantable system | PACESETTER, INC. | 2001-12-11 | — | — | US | claimed |
| US-5235979-A | Dual battery system for implantable defibrillator | ANGEION, CORPORATION (US) | 1993-08-17 | — | — | US | claimed |
| US-10092759-B2 | Self-learning method and device for managing intracardiac cycle extension | PACESETTER, INC. (US) | 2018-10-09 | — | — | US | disclosed |
| US-20170106191-A1 | SELF-LEARNING METHOD AND DEVICE FOR MANAGING INTRACARDIAC CYCLE EXTENSION | PACESETTER, INC. | 2017-04-20 | — | — | US | disclosed |
| US-8086308-B2 | Implantable medical device for identifying and managing intrinsic reentrant tachycardia | PACESETTER, INC. (US) | 2011-12-27 | — | — | US | disclosed |
| US-7986993-B1 | Implantable cardiac device providing AV interval hysteresis to promote intrinsic conduction while providing PMT avoidance and method | PACESETTER, INC. (US) | 2011-07-26 | — | — | US | disclosed |
| US-7945327-B2 | Systems and methods for monitoring and managing power consumption of an implantable medical device | CARDIAC PACEMAKERS, INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7877145-B2 | Systems and methods for managing the longevity of an implantable medical device battery | CARDIAC PACEMAKERS, INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-7620452-B1 | Systems and methods for managing the longevity of an implantable medical device battery | CARDIAC PACEMAKERS, INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-20090069861-A1 | SYSTEMS AND METHODS FOR MONITORING AND MANAGING POWER CONSUMPTION OF AN IMPLANTABLE MEDICAL DEVICE | CARDIAC PACEMAKERS, INC. | 2009-03-12 | — | — | US | disclosed |
| US-20090005828-A1 | IMPLANTABLE MEDICAL DEVICE FOR IDENTIFYING AND MANAGING INTRINSIC REENTRANT TACHYCARDIA | PACESETTER, INC. (US) | 2009-01-01 | — | — | US | disclosed |
| US-5405363-A | Implantable cardioverter defibrillator having a smaller displacement volume | ANGELON CORPORATION (US) | 1995-04-11 | — | — | US | disclosed |
| US-5383907-A | System and method for delivering multiple closely spaced defibrillation pulses | ANGEION CORPORATION (US) | 1995-01-24 | — | — | US | disclosed |
| US-5372605-A | Dual battery power system for an implantable cardioverter defibrillator | ANGEION CORPORATION (US) | 1994-12-13 | — | — | US | disclosed |
| WO-1994002202-A1 | DUAL BATTERY SYSTEM FOR IMPLANTABLE CARDIOVERTER DEFIBRILLATOR | ANGEMED, INC. (US) | 1994-02-03 | — | — | WO | disclosed |
| US-5191884-A | For treating a tachyrhythmia of the heart | TELECTRONICS N.V. (AN) | 1993-03-09 | — | — | US | disclosed |
| US-5083562-A | Method and apparatus for applying asymmetric biphasic truncated exponential countershocks | TELECTRONICS PACING SYSTEMS, INC. (US) | 1992-01-28 | — | — | US | disclosed |
| EP-0331697-A4 | RECONFIRMATION PRIOR TO SHOCK FOR IMPLANTABLE DEFIBRILLATION | — | 1991-10-16 | — | — | EP | disclosed |
| EP-0331697-A1 | RECONFIRMATION PRIOR TO SHOCK FOR IMPLANTABLE DEFIBRILLATION | TELECTRONICS PTY. LIMITED (AU) | 1989-09-13 | — | — | EP | disclosed |
| WO-1989001802-A1 | RECONFIRMATION PRIOR TO SHOCK FOR IMPLANTABLE DEFIBRILLATION | TELECTRONICS PTY. LIMITED (AU) | 1989-03-09 | — | — | WO | disclosed |