SCHEMBL9749277

SCHEMBL9749277

COC(=O)CC(C)c1nsnc1OCC(O)CNCCNC(=O)c1c[nH]c2ccccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.38
PRMT5 O14744 1/20 0.38
WDR77 Q9BQA1 1/20 0.38
HDAC1 Q13547 2/20 0.37
HDAC2 Q92769 2/20 0.37
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9750388 0.93 HTR4 (0.40) PRMT5WDR77
SCHEMBL9750403 0.85 HDAC1 (0.39) ALOX5PRMT5WDR77HDAC1HDAC2
SCHEMBL9749921 0.84 ADRB1 (0.47) ADRB2ADRB1ADRB3
SCHEMBL9749280 0.83 DRD3 (0.41) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL9749808 0.80 HTR4 (0.42) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL10984391 0.80 ADRB1 (0.45) ADRB2ADRB1ADRB3
SCHEMBL10991811 0.79 ADRB1 (0.43) SMN1; SMN2ADRB2ADRB1ADRB3LMNA
SCHEMBL9749947 0.77 ADRB2 (0.45) ADRB2ADRB1ADRB3
SCHEMBL9750393 0.76 DRD3 (0.42)
SCHEMBL10984397 0.74 KDM4E (0.42) MEN1KMT2AADRB2ADRB1ADRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0131006-B1 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-06-10 EP disclosed
EP-0131006-A4 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. AMERICAN HOSPITAL SUPPLY CORP (US) 1985-06-06 EP disclosed
US-4508725-A BETA-ADRENERGIC BLOCKING AGENTS; GLAUCOMA TREATMENT AMERICAN HOSPITAL SUPPLY CORPORATION (US) 1985-04-02 US disclosed
EP-0131006-A1 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. AMERICAN HOSPITAL SUPPLY CORP (US) 1985-01-16 EP disclosed
WO-1984002525-A1 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES AMERICAN HOSPITAL SUPPLY CORP (US) 1984-07-05 WO disclosed