SCHEMBL9750403

SCHEMBL9750403

COC(=O)CCc1nsnc1OCC(O)CNCCNC(=O)c1c[nH]c2ccccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.39
HDAC2 Q92769 2/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
ALOX5 P09917 2/20 0.39
PRMT5 O14744 1/20 0.38
WDR77 Q9BQA1 1/20 0.38
LMNA P02545 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
ROCK2 O75116 1/20 0.37
ROCK1 Q13464 1/20 0.37
CDK4 P11802 1/20 0.36
CCND1 P24385 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9749808 0.93 HTR4 (0.42) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL9749277 0.85 ALOX5 (0.38) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL9749960 0.84 ADRB1 (0.48) ADRB2ADRB1ADRB3
SCHEMBL9750418 0.82 DRD3 (0.42) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL9750388 0.80 HTR4 (0.40) PRMT5WDR77
SCHEMBL10980083 0.79 ADRB1 (0.45) LMNAADRB2ADRB1ADRB3
SCHEMBL10460530 0.79 ADRB2 (0.36) ADRB2ADRB1ADRB3
SCHEMBL10993319 0.77 ADRB2 (0.41) ADRB2ADRB1ADRB3
SCHEMBL9750379 0.77 ADRB2 (0.46) ADRB2ADRB1ADRB3
SCHEMBL10979580 0.76 DRD2 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0131006-B1 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-06-10 EP disclosed
EP-0131006-A4 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. AMERICAN HOSPITAL SUPPLY CORP (US) 1985-06-06 EP disclosed
US-4508725-A BETA-ADRENERGIC BLOCKING AGENTS; GLAUCOMA TREATMENT AMERICAN HOSPITAL SUPPLY CORPORATION (US) 1985-04-02 US disclosed
EP-0131006-A1 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. AMERICAN HOSPITAL SUPPLY CORP (US) 1985-01-16 EP disclosed
WO-1984002525-A1 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES AMERICAN HOSPITAL SUPPLY CORP (US) 1984-07-05 WO disclosed