Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749277 | 0.93 | ALOX5 (0.38) | PRMT5WDR77 | |
| SCHEMBL9749808 | 0.86 | HTR4 (0.42) | HTR4CYP2D6 | |
| SCHEMBL9749947 | 0.85 | ADRB2 (0.45) | ALDH1A1 | |
| SCHEMBL9750393 | 0.84 | DRD3 (0.42) | ALDH1A1 | |
| SCHEMBL10984375 | 0.80 | ADRB1 (0.43) | — | |
| SCHEMBL9750403 | 0.80 | HDAC1 (0.39) | PRMT5WDR77 | |
| SCHEMBL10993894 | 0.80 | ADRB2 (0.43) | — | |
| SCHEMBL9749921 | 0.77 | ADRB1 (0.47) | ALDH1A1CYP2D6 | |
| SCHEMBL9749280 | 0.76 | DRD3 (0.41) | ALDH1A1 | |
| SCHEMBL10984379 | 0.75 | KDM4E (0.40) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0131006-B1 | ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-06-10 | — | — | EP | disclosed |
| EP-0131006-A4 | ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1985-06-06 | — | — | EP | disclosed |
| US-4508725-A | BETA-ADRENERGIC BLOCKING AGENTS; GLAUCOMA TREATMENT | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-04-02 | — | — | US | disclosed |
| EP-0131006-A1 | ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1985-01-16 | — | — | EP | disclosed |
| WO-1984002525-A1 | ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES | AMERICAN HOSPITAL SUPPLY CORP (US) | 1984-07-05 | — | — | WO | disclosed |