Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.46 |
| ▸ | TOP1 | P11387 | 2/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749310 | 0.90 | LMNA (0.41) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9749297 | 0.88 | KDM4E (0.50) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10425974 | 0.88 | KDM4E (0.50) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9750401 | 0.86 | KDM4E (0.53) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9749343 | 0.83 | KDM4E (0.61) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10425073 | 0.83 | KDM4E (0.70) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL9869685 | 0.83 | LMNA (0.68) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9749353 | 0.83 | KCNH2 (0.55) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL9749882 | 0.83 | KDM4E (0.51) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9749281 | 0.80 | LMNA (0.50) | LMNAMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216345-B1 | QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-19 | — | — | EP | disclosed |
| US-4977265-A | WITH BACTERICIDAL ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4946847-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4806541-A | ANTIBACTERIAL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0216345-A2 | Quinoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-04-01 | — | — | EP | disclosed |