Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926127 | 0.87 | L3MBTL1 (0.42) | KDM4ELMNAALDH1A1SRD5A2MAPT | |
| SCHEMBL9749890 | 0.86 | MAPT (0.47) | KDM4ELMNAALDH1A1MAPTPOLB | |
| SCHEMBL10510005 | 0.84 | SRD5A2 (0.43) | KDM4ELMNAALDH1A1SRD5A2GABRA1 | |
| SCHEMBL9749856 | 0.82 | TRPM8 (0.45) | KDM4ESRD5A2GABRA1GABRG2GABRB3 | |
| SCHEMBL27251939 | 0.81 | MAPT (0.45) | KDM4ELMNASRD5A2MAPTERN1 | |
| SCHEMBL10924754 | 0.80 | ALDH1A1 (0.40) | KDM4ELMNAALDH1A1MAPTRAB9A | |
| SCHEMBL10925785 | 0.79 | SRD5A2 (0.46) | SRD5A2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11290618 | 0.79 | SRD5A2 (0.46) | KDM4ELMNASRD5A2MAPTERN1 | |
| SCHEMBL10508275 | 0.79 | SRD5A2 (0.57) | KDM4EALDH1A1SRD5A2MAPTPOLB | |
| SCHEMBL9749833 | 0.79 | SRD5A2 (0.39) | LMNAALDH1A1SRD5A2GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266349-B1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-18 | — | — | EP | disclosed |
| EP-0266349-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES. | SCHERING AG (DE) | 1988-05-11 | — | — | EP | disclosed |
| WO-1987000522-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1987-01-29 | — | — | WO | disclosed |
| EP-0062919-B1 | INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-07-30 | — | — | EP | disclosed |
| EP-0062919-A1 | Indole derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-10-20 | — | — | EP | disclosed |