Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749326 | 0.86 | KDM4E (0.40) | MAPTLMNAALDH1A1HPGDNPC1 | |
| SCHEMBL9749833 | 0.81 | SRD5A2 (0.39) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9749856 | 0.76 | TRPM8 (0.45) | MAPTKDM4E | |
| SCHEMBL9749338 | 0.74 | MAPT (0.55) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL10925785 | 0.74 | SRD5A2 (0.46) | MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL9749330 | 0.74 | MAPT (0.55) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL10926127 | 0.73 | L3MBTL1 (0.42) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL10926951 | 0.71 | MAPT (0.35) | MAPTALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL10510005 | 0.71 | SRD5A2 (0.43) | MAPTLMNAALDH1A1HPGDNPC1 | |
| SCHEMBL10926398 | 0.69 | L3MBTL1 (0.46) | MAPTLMNAALDH1A1HPGDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266349-B1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-18 | — | — | EP | disclosed |
| EP-0266349-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES. | SCHERING AG (DE) | 1988-05-11 | — | — | EP | disclosed |
| WO-1987000522-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1987-01-29 | — | — | WO | disclosed |