Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749856 | 0.87 | TRPM8 (0.45) | SRD5A2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL9749300 | 0.86 | SRD5A2 (0.41) | SRD5A2SRD5A1PTGER1PTGER4PTGER3 | |
| SCHEMBL9749890 | 0.81 | MAPT (0.47) | CYP19A1ALDH1A1LMNAPOLBHTT | |
| SCHEMBL9749326 | 0.79 | KDM4E (0.40) | SRD5A2FFAR4GABRA1GABRG2GABRB3 | |
| SCHEMBL10925785 | 0.75 | SRD5A2 (0.46) | SRD5A2SRD5A1PTGER1GABRA1GABRG2 | |
| SCHEMBL9749866 | 0.73 | LTA4H (0.46) | TRPM8ALDH1A1LMNAPOLBHTT | |
| SCHEMBL10926951 | 0.73 | MAPT (0.35) | SRD5A2SRD5A1GABRA1GABRG2GABRB3 | |
| SCHEMBL10926398 | 0.70 | L3MBTL1 (0.46) | SRD5A2PTGER1TRPM8GABRA1GABRG2 | |
| SCHEMBL10927491 | 0.69 | SMN1; SMN2 (0.34) | SRD5A2SRD5A1TRPM8GABRA1GABRG2 | |
| SCHEMBL18886838 | 0.66 | ALDH1A1 (0.61) | SRD5A2TRPM8GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266349-B1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-18 | — | — | EP | claimed |
| EP-0266349-B1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-18 | — | — | EP | disclosed |
| EP-0266349-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES. | SCHERING AG (DE) | 1988-05-11 | — | — | EP | disclosed |
| WO-1987000522-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1987-01-29 | — | — | WO | disclosed |