Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 6/20 | 0.42 |
| ▸ | CTSV | O60911 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307738 | 0.77 | BRD4 (0.48) | BTKBRD4CTSVCTSLMAPT | |
| SCHEMBL11083877 | 0.77 | SGMS2 (0.55) | CTSVCTSLMAPTL3MBTL1NPC1 | |
| SCHEMBL9749866 | 0.75 | LTA4H (0.46) | BTKBRD4MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL9749338 | 0.74 | MAPT (0.55) | BRD4MAPTSMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL9749330 | 0.74 | MAPT (0.55) | BRD4MAPTSMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL10685914 | 0.74 | NPC1 (0.41) | BTKBRD4MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8303620 | 0.72 | LTA4H (0.53) | BTKBRD4MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL31211593 | 0.72 | CTSV (0.52) | CTSVCTSLMAPTTDP1L3MBTL1 | |
| SCHEMBL8303606 | 0.72 | LTA4H (0.46) | BRD4MAPTSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL27527029 | 0.72 | LTA4H (0.46) | BRD4CTSVCTSLMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266349-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES. | SCHERING AG (DE) | 1988-05-11 | — | — | EP | disclosed |
| WO-1987000522-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1987-01-29 | — | — | WO | disclosed |