Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749973 | 0.81 | LTA4H (0.68) | LTA4HPLA2G2ATRPM8BRD4MAPT | |
| SCHEMBL8303620 | 0.78 | LTA4H (0.53) | LTA4HPLA2G2ATRPM8BRD4MAPT | |
| SCHEMBL10685914 | 0.75 | NPC1 (0.41) | LTA4HPLA2G2ATRPM8BRD4MAPT | |
| SCHEMBL9749338 | 0.75 | MAPT (0.55) | LTA4HPLA2G2ATRPM8BRD4MAPT | |
| SCHEMBL9749330 | 0.75 | MAPT (0.55) | LTA4HPLA2G2ATRPM8BRD4MAPT | |
| SCHEMBL10679463 | 0.75 | BTK (0.42) | LTA4HPLA2G2ATRPM8BRD4MAPT | |
| SCHEMBL9749300 | 0.74 | SRD5A2 (0.41) | BRD4MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9749833 | 0.73 | SRD5A2 (0.39) | TRPM8MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL8303606 | 0.72 | LTA4H (0.46) | LTA4HPLA2G2ATRPM8BRD4MAPT | |
| SCHEMBL3621324 | 0.72 | LTA4H (0.46) | LTA4HPLA2G2ATRPM8BRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266349-B1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-18 | — | — | EP | claimed |
| EP-0266349-B1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-18 | — | — | EP | disclosed |
| EP-0266349-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES. | SCHERING AG (DE) | 1988-05-11 | — | — | EP | disclosed |
| WO-1987000522-A1 | TRICYCLIC INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1987-01-29 | — | — | WO | disclosed |