Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 10/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PGC | P20142 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749523 | 0.90 | CACNA1B (0.43) | RENGAACYP3A4CTSSCTSK | |
| SCHEMBL9876609 | 0.90 | REN (0.44) | RENL3MBTL1CYP3A4CTSSCTSK | |
| SCHEMBL9749944 | 0.89 | CTSS (0.37) | RENCYP3A4CTSSCTSKCACNA1B | |
| SCHEMBL10762000 | 0.87 | CTSS (0.41) | RENCYP3A4CTSSCTSKCACNA1B | |
| SCHEMBL9876362 | 0.87 | CTSS (0.41) | RENCYP3A4CTSSCTSKCACNA1B | |
| SCHEMBL9750052 | 0.85 | CTSS (0.39) | RENCYP3A4CTSSCTSKCACNA1B | |
| SCHEMBL9750070 | 0.85 | SCN9A (0.39) | RENCYP3A4CTSSCTSKCACNA1B | |
| SCHEMBL8894525 | 0.84 | CTSS (0.39) | CTSLRENCYP3A4CTSSCTSK | |
| SCHEMBL7442988 | 0.84 | CTSS (0.39) | CTSLRENCYP3A4CTSSCTSK | |
| SCHEMBL8852922 | 0.84 | CACNA1B (0.47) | RENALDH1A1CTSSCTSKEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212903-B1 | POLYPEPTIDE DERIVATIVES CONTAINING 5-AMINO-2,5-DISUBSTITUTED-4-HYDROXYPENTANOIC ACID RESIDUES | PFIZER INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0212903-A2 | Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1987-03-04 | — | — | EP | disclosed |