Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.38 |
| ▸ | REN | P00797 | 6/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894525 | 0.92 | CTSS (0.39) | CTSSCTSKCACNA1BRENCYP3A4 | |
| SCHEMBL9749523 | 0.92 | CACNA1B (0.43) | CTSSCTSKCACNA1BRENCYP3A4 | |
| SCHEMBL7442988 | 0.92 | CTSS (0.39) | CTSSCTSKCACNA1BRENCYP3A4 | |
| SCHEMBL9876609 | 0.92 | REN (0.44) | CTSSCTSKRENCYP3A4 | |
| SCHEMBL8852922 | 0.91 | CACNA1B (0.47) | CTSSCTSKCACNA1BRENPPARG | |
| SCHEMBL7425454 | 0.90 | CTSK (0.43) | CTSSCTSKCACNA1BRENCYP3A4 | |
| SCHEMBL9749944 | 0.88 | CTSS (0.37) | CTSSCTSKCACNA1BRENCYP3A4 | |
| SCHEMBL10762000 | 0.87 | CTSS (0.41) | CTSSCTSKCACNA1BRENCYP3A4 | |
| SCHEMBL9876362 | 0.87 | CTSS (0.41) | CTSSCTSKCACNA1BRENCYP3A4 | |
| SCHEMBL8462171 | 0.87 | PSMB1 (0.43) | CTSSCTSKCACNA1BRENSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212903-B1 | POLYPEPTIDE DERIVATIVES CONTAINING 5-AMINO-2,5-DISUBSTITUTED-4-HYDROXYPENTANOIC ACID RESIDUES | PFIZER INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |