Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | METAP1 | P53582 | 2/20 | 0.40 |
| ▸ | REN | P00797 | 7/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876362 | 1.00 | CTSS (0.41) | CTSSCTSKCTSBMETAP2METAP1 | |
| SCHEMBL9876609 | 0.90 | REN (0.44) | CTSSCTSKRENCYP3A4 | |
| SCHEMBL9749944 | 0.87 | CTSS (0.37) | CTSSCTSKRENCACNA1BCYP3A4 | |
| SCHEMBL8852922 | 0.87 | CACNA1B (0.47) | CTSSCTSKRENCACNA1B | |
| SCHEMBL9750052 | 0.87 | CTSS (0.39) | CTSSCTSKRENCACNA1BCYP3A4 | |
| SCHEMBL9749519 | 0.87 | CTSL (0.41) | CTSSCTSKRENCACNA1BCYP3A4 | |
| SCHEMBL7442988 | 0.86 | CTSS (0.39) | CTSSCTSKRENCACNA1BCYP3A4 | |
| SCHEMBL9749523 | 0.86 | CACNA1B (0.43) | CTSSCTSKRENCACNA1BCYP3A4 | |
| SCHEMBL8894525 | 0.86 | CTSS (0.39) | CTSSCTSKRENCACNA1BCYP3A4 | |
| SCHEMBL8462171 | 0.86 | PSMB1 (0.43) | CTSSCTSKCTSBRENCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212903-A2 | Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1987-03-04 | — | — | EP | disclosed |