Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749935 | 0.83 | ABCB1 (0.38) | ALDH1A1TSHRABCB1LMNA | |
| SCHEMBL9750379 | 0.81 | ADRB2 (0.46) | — | |
| SCHEMBL9749911 | 0.78 | ABCB1 (0.39) | TSHRABCB1 | |
| SCHEMBL9750398 | 0.78 | DRD2 (0.39) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10372339 | 0.75 | LMNA (0.39) | ALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL9749786 | 0.75 | CHRM1 (0.33) | ALDH1A1LMNASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL10976749 | 0.73 | SMN1; SMN2 (0.40) | ABCB1SMN1; SMN2 | |
| SCHEMBL10976741 | 0.72 | ADRB1 (0.43) | TSHRABCB1LMNASMN1; SMN2 | |
| SCHEMBL9749811 | 0.72 | ADRB2 (0.47) | SMN1; SMN2 | |
| SCHEMBL9749960 | 0.72 | ADRB1 (0.48) | ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0131006-B1 | ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-06-10 | — | — | EP | disclosed |
| EP-0131006-A4 | ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1985-06-06 | — | — | EP | disclosed |
| US-4508725-A | BETA-ADRENERGIC BLOCKING AGENTS; GLAUCOMA TREATMENT | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-04-02 | — | — | US | disclosed |
| EP-0131006-A1 | ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1985-01-16 | — | — | EP | disclosed |
| WO-1984002525-A1 | ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES | AMERICAN HOSPITAL SUPPLY CORP (US) | 1984-07-05 | — | — | WO | disclosed |