SCHEMBL9750398

SCHEMBL9750398

CCN(CC(O)COc1nsnc1CCC(=O)OC)NC(=O)c1cc2ccccc2[nH]1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 0.39
DRD3 P35462 2/20 0.39
HPGD P15428 2/20 0.37
GAA P10253 2/20 0.37
CCKBR P32239 4/20 0.37
KDM4E B2RXH2 3/20 0.36
ALDH1A1 P00352 3/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HSD17B10 Q99714 1/20 0.36
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
MAPK1 P28482 1/20 0.35
HTR2C P28335 1/20 0.35
PDGFRB P09619 2/20 0.35
PDGFRA P16234 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
HSPA5 P11021 1/20 0.34
HSPA8 P11142 1/20 0.34
HSPA9 P38646 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9749806 0.94 CCKBR (0.39) DRD2DRD3HPGDGAACCKBR
SCHEMBL9749273 0.85 DRD2 (0.39) DRD2DRD3HPGDGAACCKBR
SCHEMBL9750418 0.82 DRD3 (0.42) DRD2DRD3KDM4EALDH1A1HSD17B10
SCHEMBL9750383 0.81 DRD2 (0.38) DRD2DRD3HPGDGAACCKBR
SCHEMBL9750371 0.78 ALDH1A1 (0.36) KDM4EALDH1A1SMN1; SMN2HSD17B10NPC1
SCHEMBL10979580 0.77 DRD2 (0.42) DRD2DRD3KDM4EALDH1A1HTR2C
SCHEMBL23111879 0.71 DRD2 (0.64) DRD2DRD3HPGDGAAKDM4E
SCHEMBL9749863 0.69 ADRB2 (0.33) KDM4ESMN1; SMN2DRD1
SCHEMBL9749280 0.67 DRD3 (0.41) DRD2DRD3KDM4EALDH1A1HSD17B10
SCHEMBL9749960 0.66 ADRB1 (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0131006-B1 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-06-10 EP disclosed
EP-0131006-A4 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. AMERICAN HOSPITAL SUPPLY CORP (US) 1985-06-06 EP disclosed
US-4508725-A BETA-ADRENERGIC BLOCKING AGENTS; GLAUCOMA TREATMENT AMERICAN HOSPITAL SUPPLY CORPORATION (US) 1985-04-02 US disclosed
EP-0131006-A1 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES. AMERICAN HOSPITAL SUPPLY CORP (US) 1985-01-16 EP disclosed
WO-1984002525-A1 ESTERS OF 3-(3-SUBSTITUTED-AMINO-2-HYDROXYPROPOXY)-4-SUBSTITUTED-1,2,5-THIADIAZOLE DERIVATIVES AMERICAN HOSPITAL SUPPLY CORP (US) 1984-07-05 WO disclosed