SCHEMBL9751041

SCHEMBL9751041

Cc1cc(C2C=CCC2)c(N)cc1N

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.35
ALDH1A1 P00352 2/20 0.34
CYP1A2 P05177 1/20 0.34
ALOX15 P16050 1/20 0.34
CASP7 P55210 1/20 0.34
HIF1A Q16665 1/20 0.34
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9750929 0.76
SCHEMBL8292041 0.74 NOS3 (0.37)
SCHEMBL10477482 0.73 CHRNB2 (0.33) CYP3A4ALDH1A1CASP7HSD17B10
SCHEMBL9751038 0.70 CYP3A4 (0.34) CYP3A4TSHR
SCHEMBL9819248 0.69 CYP3A4 (0.41) CYP3A4TSHRMAPK1ALDH1A1CYP1A2
SCHEMBL10582966 0.69 NR4A1 (0.42) ALDH1A1ALOX15
SCHEMBL10582753 0.69 ALDH1A1 (0.40) CYP3A4TSHRALDH1A1ALOX15HSD17B10
SCHEMBL16398264 0.68 HTR2C (0.44) TSHR
SCHEMBL10399467 0.68 CYP3A4 (0.35) CYP3A4ALDH1A1ALOX15CASP7
SCHEMBL16398268 0.68 HTR2C (0.44) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5072045-A Polymerization inhibition using inert organic solvent AIR PRODUCTS AND CHEMICALS, INC. (US) 1991-12-10 US disclosed
US-4985159-A Alkenylated toluenediamines as antioxidants for organic materials AIR PRODUCTS AND CHEMICALS, INC. (US) 1991-01-15 US disclosed
US-4845291-A ANTIOXIDATNS, CHAIN EXTENDERS FOR POLYURETHANES AND/OR POLYUREAS AIR PRODUCTS AND CHEMICALS, INC. (US) 1989-07-04 US disclosed
US-4794194-A Alkenylated toluenediisocyanates for use in preparing polyurethane urea systems AIR PRODUCTS AND CHEMICALS, INC. (US) 1988-12-27 US disclosed
EP-0277596-A2 Amino-beta-Alkyl styrenes for use in preparing polyurethane/urea systems and polymers AIR PRODUCTS AND CHEMICALS, INC. (US) 1988-08-10 EP disclosed
EP-0272650-A1 Diamino-beta-alkylstyrenes for use in preparing polyurethane/urea systems AIR PRODUCTS AND CHEMICALS, INC. (US) 1988-06-29 EP disclosed
US-4714778-A Alkenylated toluenediamines for use in preparing polyurethane/urea systems AIR PRODUCTS AND CHEMICALS, INC. (US) 1987-12-22 US disclosed
EP-0235825-A2 Alkenylated toluenediamines for use in preparing polyurethane/urea systems AIR PRODUCTS AND CHEMICALS, INC. (US) 1987-09-09 EP disclosed