Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9674028 | 0.71 | AKR1B1 (0.40) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9672018 | 0.66 | AKR1B1 (0.69) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL10929989 | 0.65 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL10345515 | 0.64 | AKR1B1 (0.55) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9671705 | 0.61 | AKR1B1 (0.61) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9672965 | 0.60 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL10929003 | 0.60 | AKR1B1 (0.60) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL19240430 | 0.59 | S1PR4 (0.34) | — | |
| SCHEMBL9751204 | 0.59 | AKR1A1 (0.66) | AKR1B1AKR1A1 | |
| SCHEMBL27997101 | 0.58 | TGFBR1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0306525-A4 | USE OF ALDOSE REDUCTASE INHIBITORS TO ENHANCE INSULIN SENSITIVITY IN DIABETES MELLITUS | — | 1991-04-24 | — | — | EP | disclosed |
| EP-0306525-A1 | USE OF ALDOSE REDUCTASE INHIBITORS TO ENHANCE INSULIN SENSITIVITY IN DIABETES MELLITUS | ALCON LABORATORIES, INC. (US) | 1989-03-15 | — | — | EP | disclosed |
| WO-1988006887-A1 | USE OF ALDOSE REDUCTASE INHIBITORS TO ENHANCE INSULIN SENSITIVITY IN DIABETES MELLITUS | ALCON LABORATORIES, INC. (US) | 1988-09-22 | — | — | WO | disclosed |