Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.40 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.31 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.30 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10929989 | 0.74 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9672184 | 0.73 | AKR1B1 (0.46) | AKR1B1AKR1A1 | |
| SCHEMBL9751242 | 0.71 | AKR1B1 (0.41) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9672018 | 0.65 | AKR1B1 (0.69) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL10930896 | 0.64 | AKR1B1 (0.56) | AKR1B1AKR1A1 | |
| SCHEMBL9672080 | 0.64 | KMT2A (0.39) | AGBL2 | |
| SCHEMBL10345515 | 0.63 | AKR1B1 (0.55) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9672248 | 0.62 | AGBL2 (0.36) | AGBL2 | |
| SCHEMBL9672965 | 0.62 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9671705 | 0.60 | AKR1B1 (0.61) | AKR1B1AKR1B10AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153211-A | Enzyme inhibitors | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5070100-A | COMPLICATIONS OF DIABETES | ALCON LABORATORIES, INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4864028-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1989-09-05 | — | — | US | disclosed |