Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 3/20 | 0.32 |
| ▸ | CES1 | P23141 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6385367 | 0.73 | OPRM1 (0.30) | OPRM1 | |
| SCHEMBL10872352 | 0.71 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2A | |
| SCHEMBL11386287 | 0.71 | ALDH1A1 (0.47) | ALDH1A1OPRM1HDAC4 | |
| SCHEMBL10577287 | 0.70 | OPRM1 (0.32) | LMNAALDH1A1L3MBTL1OPRM1 | |
| SCHEMBL9751463 | 0.67 | ALDH1A1 (0.36) | LMNAF2AKR1C1ALDH1A1MEN1 | |
| SCHEMBL27746475 | 0.66 | AKR1C1 (0.42) | LMNAF2AKR1C1CES2CES1 | |
| SCHEMBL5168259 | 0.63 | OPRM1 (0.38) | LMNAAKR1C1CES2CES1ALDH1A1 | |
| SCHEMBL434296 | 0.62 | KMT2A (0.33) | AKR1C1ALDH1A1RAB9ABLMMEN1 | |
| SCHEMBL4666989 | 0.62 | CYP2C9 (0.33) | LMNAAKR1C1ALDH1A1BLMMEN1 | |
| SCHEMBL3819684 | 0.62 | P2RX1 (0.33) | RAB9AMEN1KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0396709-A4 | HUMAN LEUKOCYTE ELASTASE INHIBITORS AND METHODS OF PRODUCING AND USING SAME | — | 1991-05-22 | — | — | EP | disclosed |
| EP-0396709-A1 | HUMAN LEUKOCYTE ELASTASE INHIBITORS AND METHODS OF PRODUCING AND USING SAME | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1990-11-14 | — | — | EP | disclosed |