Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.89 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.89 |
| ▸ | MEN1 | O00255 | 1/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.89 |
| ▸ | POLB | P06746 | 1/20 | 0.89 |
| ▸ | GAA | P10253 | 1/20 | 0.89 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.89 |
| ▸ | HPGD | P15428 | 1/20 | 0.89 |
| ▸ | TSHR | P16473 | 1/20 | 0.89 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.89 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.89 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.89 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | DHFR | P00374 | 7/20 | 0.61 |
| ▸ | GART | P22102 | 2/20 | 0.61 |
| ▸ | ATIC | P31939 | 2/20 | 0.61 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.54 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Folic Acid SCHEMBL8956351 | 1.00 | TYMS (0.89) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL28105733 | 0.96 | TYMS (0.82) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL8466887 | 0.95 | TYMS (0.87) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL991371 | 0.95 | TYMS (0.87) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL27601535 | 0.95 | TYMS (0.87) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL23219019 | 0.95 | TYMS (0.92) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL706319 | 0.95 | TYMS (0.92) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL3877 | 0.94 | TYMS (1.00) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL332170 | 0.94 | TYMS (1.00) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Folic Acid SCHEMBL403054 | 0.94 | TYMS (1.00) | TYMSKDM4EMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470822-B2 | Folate mimetics and folate-receptor binding conjugates thereof | PURDUE RESEARCH FOUNDATION (US) | 2013-06-25 | — | — | US | disclosed |
| US-20110028714-A1 | FOLATE MIMETICS AND FOLATE-RECEPTOR BINDING CONJUGATES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-02-03 | — | — | US | disclosed |
| US-7875612-B2 | diagnostic agent comprising a contrast agent for use in medical imaging conjugated with non-peptide folic acid analog | PURDUE RESEARCH FOUNDATION (US) | 2011-01-25 | — | — | US | disclosed |
| US-20050227985-A9 | Folate mimetics and folate-receptor binding conjugates thereof | ENDOCYTE, INC. | 2005-10-13 | — | — | US | disclosed |
| EP-1389209-A4 | FOLATE MIMETICS AND FOLATE-RECEPTOR BINDING CONJUGATES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2005-04-13 | — | — | EP | disclosed |
| US-20040242582-A1 | Folate mimetics and folate-receptor binding conjugates thereof | GREEN MARK A (US) | 2004-12-02 | — | — | US | disclosed |
| EP-1389209-A1 | FOLATE MIMETICS AND FOLATE-RECEPTOR BINDING CONJUGATES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002085908-A1 | FOLATE MIMETICS AND FOLATE-RECEPTOR BINDING CONJUGATES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242582-A1 | Folate mimetics and folate-receptor binding conjugates thereof | FOLR1, FOLR2, DHFR | TYMS 20/4885KDM4E 3935/4885MEN1 1118/4885 |
| US-20050227985-A9 | Folate mimetics and folate-receptor binding conjugates thereof | FOLR1, FOLR2, DHFR | TYMS 20/4885KDM4E 3935/4885MEN1 1118/4885 |
| US-20110028714-A1 | FOLATE MIMETICS AND FOLATE-RECEPTOR BINDING CONJUGATES THEREOF | FOLR1, FOLR2, DHFR | TYMS 20/4885KDM4E 3935/4885MEN1 1118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.