Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 3/20 | 0.42 |
| ▸ | ARG2 | P78540 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753055 | 0.90 | ARG1 (0.41) | ARG1ARG2CYP3A4LMNATSHR | |
| SCHEMBL28592319 | 0.77 | ARG1 (0.39) | ARG1ARG2KMT2AMEN1TDP1 | |
| SCHEMBL9752857 | 0.76 | LMNA (0.50) | LMNAKMT2AMEN1MAPTKDM4E | |
| SCHEMBL27667817 | 0.74 | KMT2A (0.36) | CYP3A4LMNATSHRABCB11CYP1A2 | |
| SCHEMBL18828224 | 0.72 | ALDH1A1 (0.38) | CYP3A4LMNATSHRABCB11CYP1A2 | |
| SCHEMBL27667349 | 0.71 | KMT2A (0.37) | CYP3A4LMNATSHRABCB11CYP1A2 | |
| SCHEMBL17684986 | 0.68 | ARG1 (0.56) | ARG1ARG2 | |
| SCHEMBL27772736 | 0.67 | KMT2A (0.36) | TSHRCYP2D6KMT2AMEN1MAPK1 | |
| SCHEMBL28683111 | 0.67 | EPHX2 (0.37) | CYP3A4LMNATSHRABCB11CYP1A2 | |
| SCHEMBL1816006 | 0.66 | MAPK1 (0.44) | LMNATSHRKMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991007378-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1991-05-30 | — | — | WO | disclosed |