Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753676 | 0.89 | PTGS2 (0.37) | PTGS2KMT2AKDM5BNPC1RAB9A | |
| SCHEMBL9753671 | 0.89 | PTGS2 (0.37) | PTGS2KMT2AKDM5BNPC1RAB9A | |
| SCHEMBL9752959 | 0.86 | POLB (0.38) | PTGS2KMT2AALDH1A1MAPK14POLB | |
| SCHEMBL9752928 | 0.81 | MAPK14 (0.43) | PTGS2KMT2AKDM5BALDH1A1MAPK14 | |
| SCHEMBL9753207 | 0.81 | ALDH1A1 (0.40) | PTGS2NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27352605 | 0.80 | KDM4E (0.38) | PTGS2KMT2AKDM5BNPC1RAB9A | |
| SCHEMBL9753293 | 0.79 | GCGR (0.41) | PTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9753589 | 0.77 | HMGCR (0.41) | ALDH1A1CYP3A4 | |
| SCHEMBL9753322 | 0.77 | HMGCR (0.53) | ALDH1A1ESR1CYP3A4 | |
| SCHEMBL9753585 | 0.77 | HMGCR (0.41) | ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |
| CN-1056690-A | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-04 | — | — | CN | disclosed |