Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | GCGR | P47871 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | AKT2 | P31751 | 2/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753293 | 0.87 | GCGR (0.41) | GCGRSMN1; SMN2 | |
| SCHEMBL9752959 | 0.81 | POLB (0.38) | DHODHPTGDR2POLBAKT1AKT2 | |
| SCHEMBL9753368 | 0.81 | GCGR (0.51) | GCGR | |
| SCHEMBL9753066 | 0.81 | DGAT1 (0.46) | SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9752958 | 0.79 | PTGDR2 (0.39) | DHODHPTGDR2GCGRSMN1; SMN2POLB | |
| SCHEMBL9753035 | 0.78 | AKT1 (0.36) | POLBAKT1AKT2STAT1CDK1 | |
| SCHEMBL9753037 | 0.78 | AKT1 (0.36) | POLBAKT1AKT2STAT1CDK1 | |
| SCHEMBL9753309 | 0.78 | MAPK14 (0.43) | PTGDR2GCGR | |
| SCHEMBL9753771 | 0.75 | GCGR (0.40) | PTGDR2GCGR | |
| SCHEMBL9753319 | 0.74 | HMGCR (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |