SCHEMBL9753404

SCHEMBL9753404

CNCCn1c(NS(C)(=O)=O)nc2ccccc21

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.47
KDM4E B2RXH2 5/20 0.47
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
LMNA P02545 4/20 0.47
MAPT P10636 3/20 0.47
TDP1 Q9NUW8 3/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
HTT P42858 2/20 0.47
TP53 P04637 2/20 0.47
HSD17B10 Q99714 2/20 0.47
HPGD P15428 1/20 0.47
ALOX15 P16050 1/20 0.47
ALDH1A1 P00352 4/20 0.46
POLB P06746 2/20 0.44
TSHR P16473 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
ALOX12 P18054 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9697129 0.83 KDM4E (0.57) GAAKDM4EMEN1KMT2ALMNA
SCHEMBL19113190 0.79 RAB9A (0.58) GAAKDM4EMEN1KMT2ALMNA
SCHEMBL16373734 0.75 PKM (0.57) LMNAMAPTHTTTP53ALDH1A1
SCHEMBL5461912 0.74 POLB (0.69) KMT2AHTTTP53POLBCYP1A2
SCHEMBL9697560 0.72 KDM4E (0.49) GAAKDM4EMEN1KMT2ALMNA
SCHEMBL21776305 0.71 TP53 (0.47) KDM4EMEN1KMT2ALMNAMAPT
SCHEMBL9753405 0.71 HSD17B10 (0.47) GAAKDM4EMEN1KMT2ALMNA
SCHEMBL10670593 0.70 LMNA (0.66) GAAMEN1KMT2ALMNAMAPT
Hydrochloric Acid SCHEMBL9695944 0.70 MEN1 (0.48) KDM4EMEN1KMT2ALMNAMAPT
SCHEMBL6204453 0.69 RAB9A (0.62) GAAKDM4EMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1991018904-A1 SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES AMERICAN HOME PRODUCTS CORPORATION (US) 1991-12-12 WO disclosed