Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8608922 | 0.76 | ALDH1A1 (0.33) | KDM4ENPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9844987 | 0.73 | EGLN1 (0.30) | KDM4ENPC1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8605684 | 0.72 | PGK1 (0.32) | KDM4EALDH1A1RAB9ANR4A2 | |
| SCHEMBL8607360 | 0.70 | ALDH1A3 (0.45) | KDM4ENPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9753722 | 0.67 | APP (0.32) | KDM4ENPC1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL8605667 | 0.67 | — | — | |
| SCHEMBL8610050 | 0.67 | TBXAS1 (0.42) | SMN1; SMN2 | |
| SCHEMBL8606962 | 0.67 | KDM6B (0.35) | KDM4ENPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8608694 | 0.66 | — | — | |
| SCHEMBL8606409 | 0.66 | ALDH1A3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | claimed |
| WO-1991008211-A1 | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY | G.D. SEARLE & CO. (US) | 1991-06-13 | — | — | WO | disclosed |