Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5051468 | 0.85 | SMN1; SMN2 (0.33) | LMNACYP1A2CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL8608573 | 0.82 | LMNA (0.33) | LMNATSHRCYP1A2CYP2C19ESR1 | |
| SCHEMBL5983433 | 0.81 | GAA (0.31) | ESR1MAPTGAA | |
| SCHEMBL6307975 | 0.76 | MAPT (0.40) | LMNASMN1; SMN2MAPTRAB9AALDH1A1 | |
| SCHEMBL5952565 | 0.76 | NPC1 (0.50) | TSHRSMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL1454369 | 0.75 | CA1 (0.54) | LMNATSHRCYP1A2CYP2C19ESR1 | |
| SCHEMBL10589588 | 0.74 | TSHR (0.41) | LMNATSHRCYP1A2CYP2C19ESR1 | |
| SCHEMBL17907572 | 0.73 | NPC1 (0.42) | LMNACYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL8948561 | 0.73 | TPMT (0.38) | GAA | |
| SCHEMBL9601827 | 0.73 | MMP1 (0.44) | LMNASMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057301-A | MODIFIED CELLULAR SUBSTRATES USED AS LINKERS FOR INCREASED CELL RETENTION OF DIAGNOSTIC AND THERAPEUTIC AGENTS | NEORX CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| WO-1991009626-A1 | PROCESS FOR ISOLATION AND RADIOLABELING OF PHARMACEUTICALS WITH ISOTOPES OF ASTATINE | NEORX CORPORATION (US) | 1991-07-11 | — | — | WO | disclosed |
| EP-0336364-A2 | Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents | NEORX CORPORATION (US) | 1989-10-11 | — | — | EP | disclosed |