Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.53 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CDC42 | P60953 | 1/20 | 0.45 |
| ▸ | RAC1 | P63000 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9754190 | 0.93 | ALOX5 (0.49) | ALOX5COPS5PTGS2AKR1C3AKR1C2 | |
| SCHEMBL9754045 | 0.85 | COPS5 (0.45) | ALOX5COPS5PTGS2AKR1C3AKR1C2 | |
| SCHEMBL9754316 | 0.83 | ALOX5 (0.48) | ALOX5 | |
| SCHEMBL9754206 | 0.79 | ALOX5 (0.53) | ALOX5COPS5PTGS2AKR1C3AKR1C2 | |
| Potassium SCHEMBL9754024 | 0.78 | ALOX5 (0.52) | ALOX5COPS5PTGS2AKR1C3AKR1C2 | |
| SCHEMBL9754018 | 0.78 | ALOX5 (0.52) | ALOX5COPS5PTGS2AKR1C3AKR1C2 | |
| SCHEMBL9754000 | 0.74 | ALOX5 (0.46) | ALOX5PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL4669037 | 0.73 | AKR1C3 (0.58) | COPS5PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL9754184 | 0.73 | COPS5 (0.47) | COPS5PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL9754402 | 0.71 | ALOX5 (0.56) | ALOX5PTGS2AKR1C3AKR1C2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | claimed |
| US-5032588-A | Non-steroidal antiinflammatory | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |