Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COPS5 | Q92905 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CDC42 | P60953 | 1/20 | 0.43 |
| ▸ | RAC1 | P63000 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9754190 | 0.89 | ALOX5 (0.49) | COPS5CYP11B1CYP11B2TDP1L3MBTL1 | |
| SCHEMBL9754071 | 0.85 | ALOX5 (0.53) | COPS5CYP11B1CYP11B2TDP1L3MBTL1 | |
| SCHEMBL1894316 | 0.72 | CA1 (0.57) | CYP11B1CYP11B2PLAUTDP1L3MBTL1 | |
| SCHEMBL9754095 | 0.71 | LMNA (0.43) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL15897010 | 0.71 | CYP11B1 (0.69) | CYP11B1CYP11B2PLAUCYP1A2MAPT | |
| SCHEMBL9754184 | 0.68 | COPS5 (0.47) | COPS5PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL1856468 | 0.68 | KDM4E (0.70) | CYP11B1CYP11B2PLAUL3MBTL1CYP1A2 | |
| SCHEMBL9754316 | 0.68 | ALOX5 (0.48) | ALOX5 | |
| SCHEMBL8993107 | 0.67 | NPC1 (0.55) | L3MBTL1LMNAMAPTMEN1ALDH1A1 | |
| SCHEMBL1289670 | 0.66 | PLA2G2A (0.57) | CYP11B1CYP11B2PLAUCYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | claimed |
| US-5032588-A | Non-steroidal antiinflammatory | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |