Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9754290 | 0.80 | ALOX5 (0.54) | ALOX5NPC1RAB9AKDM4ELMNA | |
| SCHEMBL9754002 | 0.75 | ALOX5 (0.47) | ALOX5MEN1KMT2APTGS2 | |
| SCHEMBL9629437 | 0.72 | ALOX5 (1.00) | ALOX5NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL9754071 | 0.71 | ALOX5 (0.53) | ALOX5NPC1RAB9ALMNACYP1A2 | |
| SCHEMBL9630571 | 0.70 | ALOX5 (0.53) | ALOX5TP53MAPTSMN1; SMN2 | |
| SCHEMBL8358048 | 0.69 | BCHE (0.55) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL9782162 | 0.69 | PTGS2 (0.49) | CYP1A2MAPTPTGS2 | |
| SCHEMBL9754030 | 0.68 | ALOX5 (0.44) | ALOX5MEN1KMT2APTGS2 | |
| Nabumetone SCHEMBL3362072 | 0.68 | RAB9A (0.86) | NPC1RAB9AKDM4ELMNATP53 | |
| SCHEMBL2663510 | 0.67 | CYP1A2 (0.65) | ALOX5NPC1RAB9AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |