Sugi Predict

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SCHEMBL975468

SCHEMBL975468

CC(C)(C)OC(=O)C(N)C(=O)c1cccc(NS(=O)(=O)CC2CN(C(c3ccc(Cl)cc3)c3ccc(Cl)cc3)C2)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KAT6A Q92794 1/20 0.35
▸ KAT5 Q92993 1/20 0.35
▸ EGFR P00533 1/20 0.34
▸ FGFR1 P11362 1/20 0.34
▸ KDR P35968 1/20 0.34
▸ USP2 O75604 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ TP53 P04637 4/20 0.33
▸ LMNA P02545 2/20 0.33
▸ CASR P41180 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ ANO1 Q5XXA6 1/20 0.32
▸ MDM2 Q00987 4/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ CNR1 P21554 1/20 0.32
▸ SLC6A9 P48067 1/20 0.32
▸ MAP3K5 Q99683 1/20 0.32
▸ IDH1 O75874 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL975685 0.86 EGFR (0.39) KAT6AKAT5EGFRFGFR1KDR
SCHEMBL975682 0.86 EGFR (0.39) KAT6AKAT5EGFRFGFR1KDR
SCHEMBL975471 0.85 PTPRC (0.41) KAT6AKAT5EGFRFGFR1KDR
SCHEMBL3408729 0.83 EGFR (0.40) EGFRFGFR1KDRNPC1ALDH1A1
SCHEMBL977461 0.82 MEN1 (0.44) EGFRFGFR1KDRUSP2NPC1
SCHEMBL977096 0.81 DRD2 (0.38) KAT6AKAT5EGFRFGFR1KDR
SCHEMBL977768 0.81 EGFR (0.39) EGFRFGFR1KDRNPC1ALDH1A1
SCHEMBL976516 0.78 EGFR (0.40) EGFRFGFR1KDRNPC1ALDH1A1
SCHEMBL3406222 0.78 SCN9A (0.47) EGFRFGFR1KDRLMNAMEN1
SCHEMBL976385 0.78 EGFR (0.40) EGFRFGFR1KDRNPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2234966-B1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI SA (FR) 2013-09-11 — — EP claimed
US-8445478-B2 Azetidine derivatives, their preparation and their application in therapy SANOFI (FR) 2013-05-21 — — US claimed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US claimed
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI (FR) 2013-09-12 — — US disclosed
US-8445478-B2 Azetidine derivatives, their preparation and their application in therapy SANOFI (FR) 2013-05-21 — — US disclosed
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY SANOFI-AVENTIS (FR) 2011-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237513-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B KAT6A 3684/4885KAT5 4433/4885EGFR 661/4885
US-20110009377-A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY QDPR, AZI2, ADRA1B KAT6A 3684/4885KAT5 4433/4885EGFR 661/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.